Publications

2022

C. So, K. Menelaou, J. Uraji, K. Harasimov, A.M. Steyer, K.B. Seres, J. Bucevičius, G. Lukinavičius, W. Möbius, C. Sibold, A. Tandler-Schneider, H. Eckel, R. Moltrecht, M. Blayney, K. Elder, & M. Schuh: "Mechanism of spindle pole organization and instability in human oocytes"
Science 375 (6581). DOI https://doi.org/10.1126/science.abj3944Details

2021

B. Kroppen, N. Teske, K. F. Yambire, N. Denkert, I. Mukherjee, D. Tarasenko, G. Jaipuria, M. Zweckstetter, I. Milosevic, C. Steinem, M. Meinecke: "Cooperativity of membrane‑protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin‑mediated endocytosis"
Cellular and Molecular Life Science. DOI 10.1007/s00018-020-03647-zDetails

M. Patron, D. Tarasenko, H. Nolte, M. Ghosh, Y. Ohba, Y. Lasarzewski, Z. A. Ahmadi, A. Cabrera-Orefice, A. Eyiama, T. Kellermann, E. I. Rugarli, U. Brandt, M. Meinecke, T. Langer: "Regulation of mitochondrial proteostasis by the proton gradient"
bioRxiv, in early view. DOI https://doi.org/10.1101/2021.12.12.470907Details

S. Dennerlein, S. Poerschke, S. Oeljeklaus, C. Wang, R. Richter-Dennerlein, J. Sattmann, D. Bauermeister, E. Hanitsch, S. Stoldt, T. Langer, S. Jakobs, B. Warscheid, & P. Rehling: "Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors"
eLIFE 10. DOI https://doi.org/10.7554/eLife.68213Details

H. S. Hillen, D.A. Markov, I.D. Wojtas, K.B. Hofmann, M. Lidschreiber, A.T. Cowan, J.L. Jones, D. Temiakov, P. Cramer, & M. Anikin: "The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs"
Proceedings of the National Academy of Sciences 118 (15). DOI https://doi.org/10.1073/pnas.2009329118Details

H. S. Hillen: "Structure and function of SARS-CoV-2 polymerase"
Current Opinion in Virology 48, 82-90Details

H. S. Hillen, E. Lavdovskaia, F. Nadler, E. Hanitsch, A. Linden, K.E. Bohnsack, H. Urlaub, & R. Richter-Dennerlein: "Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling"
Nature Communications 12 (1), 3672. DOI https://doi.org/10.1038/s41467-021-23702-yDetails

V. Weissert, B. Rieger, S. Morris, T. Arroum, O. E. Psathaki, T. Zobel, G. Perkins, K. B. Busch: "Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase"
BBA-Bioenergetics 1862. DOI https://doi.org/10.1016/j.bbabio.2020.148322Details

2020

A. Trevisiol, K. Kusch, A. M. Steyer, I. Gregor, C. Nardis, U. Winkler, S. Koehler, A. Restrepo, W. Moebius, H. B. Werner, K.-A. Nave, J. Hirrlinger: "Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia"
PLOS Biology 18(11). DOI https://doi.org/10.1371/journal.pbio.3000943Details

A. M. Steyer, T. Ruhwedel, C. Nardis, H. B. Werner, K.-A. Nave, W. Möbius: "Pathology of myelinated axons in the PLP-deficient mouse model of spastic paraplegia type 2 revealed by volume imaging using focused ion beamscanning electron microscopy"
Journal of Structural Biology 210. DOI https://doi.org/10.1016/j.jsb.2020.107492Details

N. A. Bonekamp, B. Peter, H. S. Hillen, A. Felser, T. Bergbrede, A. Choidas, M. Horn, A. Unger, R. di Lucrezia, I. Atanassov, X. Li, U. Koch, S. Menninger, J. Boros, P. Habenberger, P. Giavalisco, P. Cramer, M. S. Denzel, P. Nussbaumer, P. Klebl, M. Falkenberg, C. M. Gustafsson, N.-G. Larsson: "Small-molecule inhibitors of human mitochondrial DNA transcription"
Nature 588. DOI https://doi.org/10.1038/s41586-020-03048-zDetails

T. Stephan, C. Brueser, M. Deckers, A. M. Steyer, F. Balzarotti, M. Barbot, T. S. Behr, G. Heim, W. Huebner, P. Ilgen, F. Lange, D. Pacheu-Grau, J. K. Pape, S. Stoldt, T. Huser, S. W. Hell, W. Moebius, P. Rehling, D. Riedel, S. Jakobs: "MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation"
The EMBO Journal 39. DOI 10.15252/embj.2019104105Details

A. Duscha, B. Gisevius, S. Hirschberg, N. Yissachar, G. I. Stangl, E. Eilers, V. Bader, S. Haase, J. Kaisler, C. David, R. Schneider, R. Troisi, D. Zent, T. Hegelmaier, N. Dokalis, S. Gerstein, S. Del Mare-Roumani, S. Amidror, O. Staszewski, G. Poschmann, K. Stuehler, F. Hirche, A. Balogh, S. Kempa, P. Traeger, M. M. Zaiss, J. Bak Holm, M.G.Massa, H.B.Nielsen, A. Faissner, C. Lukas, S.G.Gatermann, M.Scholz, H.Przuntek, M.Prinz, S.K. Forslund, K.F. Winklhofer, D. Mueller, R.A. Linker, R. Gold, A. Haghikia: "Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism"
Cell 180. DOI https://doi.org/10.1016/j.cell.2020.02.035Details